La Mesa Prison is a penitentiary in Tijuana, Baja California near the Mexico–United States border.
In September 2008, there were two riots. The September 13 riot killed 3 inmates which was caused by inmates upset over the death of an inmate in a prison search for drugs and weapons. The September 18 riot killed 19 and injured 12 which was caused by frustration of the inmates not being given any water since the first riot.